Saturday 23 August 2008

Reproductive Dysfunctions and Alcohol Dependence Linked Among Women

� Alcohol use during the teen years can not only lead to subsequent inebriant problems, it can besides lead to risky intimate behavior and a greater risk of early childbirth. An examination of the relationship betwixt a life-time history of alcohol habituation (AD) and timing of first childbearing across procreative development has found that AD in women is associated with delayed reproduction.



Results will be published in the November issue of Alcoholism: Clinical & Experimental Research and are currently available at Early View.



"Reproductive dysfunctions include a range of catamenial disorders, sexual dysfunctions, and pregnancy complications that include spontaneous miscarriage or stillbirth," explained Mary Waldron, supporter professor of psychiatry at Washington University School of Medicine and corresponding writer for the study. "Teenagers who crapulence tend to have disruptions in their menstrual cycle as well as unplanned pregnancies."



These complications may turn more pronounced with time, added Sharon C. Wilsnack, Chester Fritz Distinguished Professor in the department of clinical neuroscience at the University of North Dakota School of Medicine & Health Sciences. "Higher rates of generative dysfunction in adult women may reflect the accumulative effects of longer exposure to alcohol for sr. women than for female adolescents," she said.



For this study, Waldron and her colleagues analyzed data gathered on two groups of Australian gemini the Twins born between 1893-1964 (3,634 female and 1,880 male person twins) and 1964-1971 (3,381 female and 2,748 male twins). Control variables included socio-demographic characteristics, regular smoking, history of psychopathology, and family and childhood risks.



Results indicate delayed reproductive oncoming among alcohol-dependent women in both groups, with slight to no effect ascertained among men.



"To our knowledge, this is the number one study to examine alcohol's effects on reproductive onslaught across generative development," aforesaid Waldron. "Most previous research has examined risks to teens or adults merely not both. Our findings highlight a risk associated with AD in women that is not wide recognized - a hazard that has assumed increasing importance disposed the increased rates of alcohol misapply by women and particularly young women."



Both Waldron and Wilsnack aforementioned the smaller effects on reproduction establish among work force may be due to the fact that women reach higher blood alcohol concentrations than men piece consuming alike amounts of alcohol - which may contribute to a stronger link 'tween drinking and reproductive problems in women. It crataegus laevigata also be, added Wilsnack, that research demonstrating prejudicial effects of alcohol manipulation on male person reproduction is not as extensive and consistent as research linking alcohol habit to female reproductive dysfunction.



"Young women wHO drink alcohol may want to consider the longer-term consequences for later childbearing," cautioned Waldron. "If drinking continues or increases to levels of problem use, their power and/or chance to experience children may be impaired."



"For women wHO are already experiencing rankness problems or other generative difficulties," added Wilsnack, "the study's findings should discourage them not to economic consumption alcohol to cope with stress caused by the reproductive problems, because alcohol would potential make the reproductive problems worse as well as carrying risks of possible alcohol blackguard or dependence."



Wilsnack recommended that future inquiry measure specific reproductive problems and their timing congener to increased drinking and symptoms of AD. This would help, she aforementioned, to clear up how much of the connection between AD and delayed reproductive memory is due to adverse effects of alcohol on reproductive operation and how much is due to reproductive problems creating bother and hurt that whitethorn be self-medicated by alcohol.




Alcoholism: Clinical & Experimental Research (ACER) is the official journal of the Research Society on Alcoholism and the International Society for Biomedical Research on Alcoholism. Co-authors of the ACER paper, "Alcohol Dependence and Reproductive Onset: Findings in Two Australian Twin Cohorts," were: Andrew C. Heath, Kathleen K. Bucholz, and Pamela A. F. Madden of the Midwest Alcoholism Research Center in the Department of Psychiatry at Washington University School of Medicine, St. Louis; and Nicholas G. Martin of the Genetic Epidemiology Unit at the Queensland Institute of Medical Research, Brisbane, Australia. The study was funded by the National Institute on Alcohol Abuse and Alcoholism, and the National Institute of Child Health and Human Development.



Source:


Mary Waldron, Ph.D.

Washington University School of Medicine



Sharon C. Wilsnack, Ph.D
University of North Dakota School of Medicine & Health Sciences


Alcoholism: Clinical & Experimental Research



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